While both terms are fundamental to pharmaceutical development, they describe distinct processes that play critical roles in tablet performance and drug delivery.
𝐃𝐢𝐬𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 refers to the physical breakdown of a tablet into smaller fragments. This is a key quality control parameter, ensuring that the tablet disintegrates as intended within a specific timeframe, enabling further drug release
𝐃𝐢𝐬𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧 is the process by which the active pharmaceutical ingredient (API) dissolves in the surrounding medium, making it available for absorption into the bloodstream. Dissolution testing evaluates the rate and extent of this release, which is directly linked to bioavailability and therapeutic efficacy
𝐖𝐡𝐲 𝐝𝐨𝐞𝐬 𝐭𝐡𝐢𝐬 𝐦𝐚𝐭𝐭𝐞𝐫?
- 𝐃𝐢𝐬𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 ensures the tablet structure breaks down as expected
- 𝐃𝐢𝐬𝐬𝐨𝐥𝐮𝐭𝐢𝐨𝐧 determines if the active ingredient is being released at the right rate and in the right amount
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