One common question in solid oral dosage packaging is the difference between PVC and PVDC blister materials.
PVC (Polyvinyl Chloride) is widely used in the pharmaceutical industry because it is cost-effective, easy to Thermo form, and suitable for many conventional tablet and capsule formulations. However, PVC provides only moderate protection against moisture and a relatively low oxygen barrier.
To enhance protection, manufacturers often use PVDC (Polyvinylidene Chloride) coated PVC. PVDC significantly improves the moisture and oxygen barrier properties, making it ideal for moisture-sensitive or stability-critical drug products.
A simple way to understand the difference:
PVC Blister
- Economical packaging option
- Moderate moisture protection
- Lower oxygen barrier
- Suitable for stable formulations
PVdC Blister
- Enhanced barrier protection
- Strong resistance to moisture and oxygen
- Suitable for sensitive formulations
- Higher packaging cost
From a regulatory and product quality perspective, the choice of blister material should always align with the stability profile of the drug product and ICH stability requirements.
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Resource Person: Kaunain Kareem Khan