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FBP based formula Scale-up

How to scale-up FBP based formula?

Which parameters should consider?

You should consider the below parameters for FBP based process scale-up:

  • Inlet Air flow
  • Atomization air pressure
  • Spray rate
FRD has reacted to this post.
FRD

@pharmaref46

Please share the scale-up formula.

Air Volume Calculation:

AV2 = AV1A1/A2

Where:
A1 = Bottom screen area of unit 1 (m2)
A2 = Bottom screen area of unit 2 (m2)
AV1 = Air volume of unit 1 (cfm)
A2 = Air volume of unit 2 (cfm)

 

Spray Rate Calculation:

SR2 = SR1AV2/AV1

Where:
SR2 = Spray rate of unit 2 (g/min)
AV2 = Air volume of unit 2 (CFM)
SR1 = Spray rate of unit 1 (g/min)
AV1 = Air volume of unit 1 (CFM)

 

Atomization Air Pressure Calculation:

AAV2 = AAV1SR2/SR1Where:
SR2 = Spray rate of unit 2 (g/min)
AAV2 = Atomizing air volume of unit 2 (CFM)
SR1 = Spray rate of unit 1 (g/min)
AAV1 = Atomizing air volume of unit 1 (CFM)