Blinding in Clinical Trials

A procedure in which one or more parties to the trial are kept unaware of the treatment assignment(s).

Single-blinding usually refers to the subject(s) being unaware, and double- blinding usually refers to the subject(s), investigator(s), monitor, and, in some cases, data analyst(s) being unaware of the treatment assignment(s).

Types of Blinding

  • Unblinded or open label: All are aware of the treatment(s)
  • Single blind or single-masked: The participants are only blinded
  • Double blind or double-masked: The participants and clinicians / data collectors are blinded

Related Topics:

Adverse Drug ReactionAcceptance CriteriaBuffer Capacity
Clinical TrialAngle of ReposeCarr’s Index

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